Abstract: In the era of Education Informatization 2.0, many medical universities will be faced with both opportunity and challenge in the in-service postgraduate students’ informatization teaching reform.Currently there are many questions about the education informatization in the in-servicemedical postgraduate students teaching. This paper discusses the reasons,the characteristics of in-servicemedical postgraduate students and the deficiencies of the simple and traditional face-to-face education.Education informatization can be applied to the informatization teaching reform by using modern information technology. Through researching on the teaching mode of in-servicemedical postgraduate students in the era of education informatization 2.0, our school caters for higher students’ abilities and better teaching result and quality.